Tianeptine sodium salt is an atypical antidepressant and a moderate μ-opioid and δ-opioid receptor agonist. It acts as a glutamate modulator, enhancing AMPA receptors and antagonizing NMDA receptors. The compound increases α1 adrenergic receptor sensitivity and offers neuroprotective, anti-inflammatory, and antioxidant effects under stress/inflammation. It inhibits MMP-9 by suppressing the PI3K/Akt-mediated NF-κB pathway, helping to alleviate depression and anxiety without sedative effects.
- Moderate μ-opioid and δ-opioid receptor agonist.
- Modulates glutamate receptors (AMPA enhancer, NMDA antagonist).
- Boosts α1 adrenergic receptor sensitivity.
- Offers neuroprotective, anti-inflammatory, and antioxidant benefits.
- Inhibits MMP-9 via PI3K/Akt-mediated NF-κB pathway.
- Reduces depression and anxiety without sedation.
- Enhances cognition and memory.
- Provides analgesic effects.